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KMID : 0613319990050010070
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Journal of the Korean Bone and Joint Tumor Soceity
1999 Volume.5 No. 1 p.70 ~ p.75
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Dedifferentiated Parosteal Osteosarcoma of the Femur -A Case Report-
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Park Hye-Rim
Park Yong-Koo
Chang Jun-Dong
Nam Eun-Suk
Sohn Jin-Hee
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Abstract
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We present a case of parosteal osteosarcoma of the femur with secondary dedifferentiation. This 57-year-old woman was radiologically diagnosed as a parosteal osteosarcoma in 1987. In 1992, excisional biopsy revealed a classical parosteal osteosarcoma with diploidy DNA pattern. In 1998, she revisited due to a recurrent tumor with pathologic fracture. The rejected specimen showed a classic parosteal osteosarcoma with area of dedifferentiation, showing high-grade spindle cell sarcoma. This dedifferentiated area revealed aneuploidy cell population on DNA flow cytometry. This case reminds us that not all parosteal osteosarcomas are low-grade lesions . Some low-grade lesions may dedifferentiate to become high grade tumors after inadequate excision.
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KEYWORD
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Osteosarcoma, Parosteal, Dedifferentiation
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